Doliprane ® syrup

paracetamol

• average Dosage: 60 mg per kg per day (maximum: 80 mg / kg / day)
• divided into four equal interval taken
• Safety and Efficacy remarkable.
• Digestive absorption rapid peak plasma concentration between 20 and 30 minutes, but effect
• antipyretic slightly slower than ibuprofen
• Presentation: syrup, sachets, tablets, suppositories.
• Two forms particularly suited to young children:

Doliprane ® syrup

• 100 ml flask or 160-kg dose is 2400 mg of paracetamol
• pipette kg
• A ml = 24 mg paracetamol
• a scale-kg = 15 mg of paracetamol
• product without sucrose replaced by maltitol and sorbitol
• (risk of diarrhea)
• Price: 1.88 € / 100 ml
• 3% pediatric Efferalgan ®
• 90 ml per bottle (total amount of paracetamol?)
• Spoon metered cup 4 to 16 kg
• a dose scale (4 kg) = 60 mg paracetamol
• sweetened with sucrose (0.67 g per dose)
• Price: 1.88 euros / 90 ml

DOLIPRANE ® 1000 mg powder for oral solution Box of 8 Sachets-dose

Doliprane: Therapeutic

Symptomatic treatment of pain of mild to moderate intensity and / or feverish.
Symptomatic treatment of pain of osteoarthritis.

Doliprane 1000mg sachet 8: Dosage and administration

Method of administration

Orally.

Pour the contents of the sachet into a glass and add a small amount of drink (eg water, milk, fruit juice). Stir and drink immediately.

Dosage

Attention: This presentation contains 1000 mg of paracetamol per unit: 2 units do not take the time .

This presentation is reserved for adults and children over 50 kg (about 15 years).

The usual dosage unit is a bag of 1000 mg per dose, to be repeated if necessary after 4 hours minimum.

It is usually not necessary to exceed 3 g of acetaminophen per day, or 3 sachets per day.

However, in case of more severe pain, the maximum dose may be increased up to 4 g per day, 4 sachets per day. Always observe an interval of 4 hours between doses.

Maximum recommended doses: see section Special warnings and precautions for use Special warnings .

Frequency of administration

Systematic decision can avoid oscillations of pain or fever:

• adults, they should be spaced at least 4 hours.

Renal

In case of severe renal impairment (creatinine clearance less than 10 ml / min), the interval between shots will be at least 8 hours.

Do not exceed 3 g paracetamol per day, or 3 sachets.

Doliprane 1 000mg bag 8: Pharmacodynamic properties

OTHER ANALGESICS AND ANTIPYRETICS

Code: ATC: N02BE01

N: Central nervous system

Paracetamol has a mechanism of central and peripheral actions.

 

Doliprane 1 000mg bag 8: Pharmacokinetic Properties

Absorption

The absorption of oral paracetamol is complete and fast. Maximum plasma concentrations are reached on average 30 to 60 minutes after ingestion.

Distribution

Paracetamol is rapidly distributed to all tissues. Concentrations are comparable in the blood, saliva and plasma. The plasma protein binding is low.

Metabolism

Paracetamol is metabolized primarily in the liver.

The two major metabolic pathways are glucuronidation and sulfation.

The latter route is rapidly saturable at doses higher than therapeutic doses. A minor pathway catalyzed by cytochrome P 450, is the formation of a reactive intermediate (N-acetyl benzoquinone imine), which under normal conditions of use, is rapidly detoxified by reduced glutathione and excreted in urine after conjugation with cysteine ​​and mercapturic acid.

However, when mass poisoning, the amount of this toxic metabolite is increased.

Elimination

Elimination is essentially urinary.

90% of the ingested dose is excreted by the kidneys within 24 hours, mainly as glucuronide (60-80%) and sulphate (20-30%). Less than 5% is excreted unchanged.

The elimination half-life is approximately 2 hours.

Pathophysiological changes

· Renal impairment :
in patients with renal impairment (creatinine clearance less than 10 ml / min), the elimination of paracetamol and its metabolites is delayed.

· Elderly :
the ability of conjugation is not changed.

DOLIPRANE 300 mg Suppositoire Boîte de 10

DOLIPRANE ® 300 mg suppository Pack of 10

Doliprane: Therapeutic

Symptomatic treatment of pain of mild to moderate intensity and / or feverish.

Doliprane 300mg sup 10: Dosage and administration

Method of administration :
Rectal. Dosage : This presentation is devoted to the childrenweighing 15 to 24 kg (approximately 4-9 years). – In children, it is imperative to respect the defined dosage depending on weight child and therefore choose a customized presentation.The approximate ages based on the weights are given for information. – The recommended daily dose of paracetamol depends on the weight of the child: it is about 60 mg / kg / day, divided into 4 doses, approximately 15 mg / kg every 6 hours. – Due to the risk of local toxicity, administration of a suppository is not recommended beyond 4 times per day, and the treatment rectally should be as short possible. – In case of diarrhea, the administration of the suppository is not recommended. – This presentation is suitable for children weighing 15 to 24 kg(approximately 4-9 years): the dose is one 300 mg suppository , repeat if necessary after 6 hours, not to exceed 4 suppositories per day . – maximum recommended doses , see warnings. administration Frequency : Catch systematic help to avoid oscillations of pain or fever in the child, they must be evenly spaced, including at night , preferably 6 hours and at least 4 hours. Renal impairment : In patients with renal impairment (creatinine clearance less than 10 ml / min), the dosing interval is at least 8 hours . 

DOLIPRANE ® 500 mg Capsule Box of 100

DOLIPRANE: the dosage

Method of administration

Orally.

The capsules should be swallowed with a drink as is (for example: water, milk, fruit juice).

The capsule is taken against-indicated in children under 6 years of age because it may cause wrong. Use another form.

Dosage

This presentation is reserved for adults and children over 27 kg (approximately from 8 years).

In children, it is imperative to respect the dosages defined according to the weight of the child and therefore choose a customized presentation. The approximate ages based on the weights are given for information.

The recommended daily dose of paracetamol is approximately 60 mg / kg / day, divided into 4 or 6 outlets, approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours.

For children with a weight of 27-40 kg (approximately 8-13 years), the dosage is 1 capsule of 500 mg per dose, to be repeated if necessary after 6 hours, not to exceed 4 capsules per day.

For children weighing 41 to 50 kg (12 to 15 years), the dosage is 1 capsule of 500 mg per dose, to be repeated if necessary after 4 hours, not to exceed 6 capsules per day.

For adults and children weighing more than 50 kg (from 15 years);

The usual unit dosage is 1 to 2 capsules of 500 mg per dose, to be repeated if necessary after 4 hours minimum.

It is usually not necessary to exceed 3 g of acetaminophen per day, or 6 capsules per day. However, in case of more severe pain, the maximum dose may be increased to 4 g per day, or 8 capsules per day.

Always an interval of 4 hours between doses.

Maximum recommended doses, see section Special warnings and precautions.

Frequency of administration

Systematic decision can avoid oscillations of pain or fever:
· The child, they must be regularly spaced, including at night, preferably 6 hours, and at least 4 hours.

· Adults, they should be spaced at least 4 hours.

Renal

In case of severe renal impairment (creatinine clearance less than 30 ml / min) the interval between two doses should be increased and be a minimum of 8 hours. Dose of acetaminophen should not exceed 3 g per day, or 6 capsules.

The daily dose lowest effective should be considered, not to exceed 60 mg / kg / day (not to exceed 3 g / day) in the following situations:

• adults less than 50 kg
• mild to moderate hepatic insufficiency
• chronic alcoholism
• chronic malnutrition
• dehydration

DOLIPRANE: its appearance and shape

Blue and yellow capsule with inscription DOLIPRANE ® (DOLI on the blue Prane on the yellow part).

DOLIPRANE ®: How it works

OTHER ANALGESICS and ANTIPYRETICS-ANILIDES, ATC code: N02BE01. N: Central nervous system.

Paracetamol has a mechanism of central and peripheral actions.

DOLIPRANE ® 1000 mg effervescent tablet scored Tube Box 1 of 8

Therapeutic Class: Analgesic
Active ingredients: Paracetamol
Status: Medicinal product not subject to medical prescription
Sale price including VAT: € 2.02
SS reimbursement rate: 65%

dosage

Method of administration

Orally.

Let fully dissolve the tablet in a glass of water. Drink immediately.

dosage

Attention: This presentation contains 1000 mg of paracetamol per unit: Do not take 2 units at a time.

This presentation is reserved for adults and children over 50 kg (about 15 years).

The usual dosage unit is half a tablet of 1000 mg per dose, to be repeated after 6 to 8 hours. If necessary, the dose may be repeated after 4 hours minimum.

It is usually not necessary to exceed 3 g of acetaminophen per day, 3 tablets per day.

However, in case of more severe pain, the maximum dose may be increased to 4 g (4 tablets) per day. Always observe an interval of 4 hours between doses.

Maximum recommended doses, see section Special warnings and precautions.

Frequency of administration

Systematic decision can avoid oscillations of pain or fever:

• Adults, they should be spaced at least 4 hours.

renal

In case of severe renal impairment (creatinine clearance less than 10 ml / min), the interval between shots will be at least 8 hours.

Do not exceed 3 g paracetamol per day, or 3 tablets.

indications against

• Hypersensitivity to paracetamol or other constituents.
• Hepatic insufficiency.

adverse

• Rare cases of hypersensitivity reactions type of anaphylactic shock, angioedema, rash, hives, skin rash have been reported. Their occurrence should be permanently discontinued this medication and related drugs.
• In very exceptional cases of thrombocytopenia, leukopenia and neutropenia were reported.